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Smoking is the leading preventable cause of death and disease in the US. Smoking claims around 400000 lives in a year. In spite of these facts about 25% of adults in the United States continue to smoke because smoking is addictive due to the presence of nicotine in cigarettes. The people who stop smoking experience unpleasant withdrawal symptoms like depressed mood, disrupted sleep , irritability, frustration, anger, anxiety, difficulty concentrating, restlessness, decreased heart rate and increased appetite or weight gain. The withdrawal symptoms are another reason for the continued high rate of people who smoke. The US Food and Drug Administration (FDA) has approved five Stop smoking medication aids all of which are effective. Among these four are nicotine replacement therapies like gum, inhaler, nasal spray and patches which relieve the smoker of withdrawal symptoms and cravings for cigarette without the dangers of carbon monoxide, tar and carcinogens. The other medication is a non-nicotine agent called Zyban or Wellbutrin.

Though Zyban is effective it is not recommended in some cases. It contains the same active ingredient that is found in Wellbutrin which is used as an anti depressant. Hence it should not be used in combination with Wellbutrin or bupropion. Overdose of Zyban might cause seizures. Hence a dose of more than 300gm/day should not be used. The risk of seizures also depends on patient factors, clinical situations and concurrent medications. Patients with a history of head trauma or prior seizure, central nervous system tumor, presence of severe hepatic cirrhosis should not use Zyban. Zyban combined with excessive use of alcohol or sedatives, addiction to opiates, cocaine or stimulants increase the chances of seizure.
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